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CIPP Industry Defends Styrene Use
Fed Dept. Seeks To Label Styrene As ‘Reasonably Anticipated Carcinogen’
To carry out the review of styrene, the NTP compiled a background document on styrene. In accordance with NTP guidelines, the human cancer, experimental animal, and mechanistic scientific information included in the background document and considered in the evaluation of styrene came from publicly available, peer-reviewed sources. The NTP also convened three, independent, scientific groups (external expert panel and two internal, Government review groups) to assess the body of scientific evidence on styrene, apply the listing criteria, and advise the NTP on whether styrene should be listed in the 12th RoC and, if so, in what classification, either known or reasonably anticipated to be a human carcinogen. The expert panel was convened at a public meeting with opportunity for comment to peer review the draft background document on styrene and provide a listing recommendation. Meetings of the two governmental, scientific review groups followed the public comment period on the expert panel's recommendation and were closed to the public.
Following the review of styrene by the three groups, the NTP considered the independent recommendations of each group, the public comments, information available in the background document, and any new, relevant scientific information on styrene, and formulated its proposed listing recommendation for styrene as reasonably anticipated to be a human carcinogen. The draft substance profile for styrene with the NTP's proposed listing recommendation was released for public comment (73 Fed. Reg. 78364, December 22, 2008) and then peer-reviewed by the NTP Board of Scientific Counselors (BSC) and additional ad hoc reviewers at a public meeting with opportunity for public comment. The BSC and ad hoc reviewers provided input to the NTP on whether the scientific information cited in the draft substance profile supported the NTP's preliminary policy decision to list styrene as reasonably anticipated to be a human carcinogen. Consistent with NTP policy, the scientific evidence cited in support of the NTP's recommendation came from publicly available, peer-reviewed sources.